The Department of Molecular Medicine is pleased to invite you to the seminar of Prof. Christophe Sirac, PhD, entitled:

A heavy load for the light chains: reproducing immunoglobulin light chain related diseases in vivo

The seminar will be held starting at 3p.m., in Room A of the Institute of Biochemistry, located in via Taramelli, 3b

The Department of Molecular Medicine, in collaboration with the A. Volta College and the Buzzati-Traverso Foundation, is pleased to invite you to the seminar of Prof. Luis Serrano Pubul (CRG - Center for Genomic Regulation - Barcelona - Spain), entitled "Engineering a bacterium for long therapy".

The seminar will be held on 11 April 2023 at Collegio A. Volta at 5 p.m.

"Engineering bacteria for treating human diseases presents new opportunities in therapeutics.
Although lung diseases are among the top causes for mortality worldwide, there is no treatment for them based on a live biotherapeutic. We have engineered a genome-reduced human lung bacterium, Mycoplasma pneumoniae (MPN), as a novel treatment for lung diseases encompassing infections, fibrosis and cancer. We found that expression of biologicals by engineered MPN has a limited physiological impact in mice due to its low expression capacity. To solve these issues, we use our protein design software FoldX and ModelX to increase the effective expression in MPN, and the activity in mouse lungs. This rational design strategy of combining synthetic biology with protein design is quite powerful to foster bacterial therapy."

For further information:

Fondazione Adriano Buzzati-Traverso c/o Dipt di Biologia e Biotecnologia, Università di Pavia. Tel +39 336747424

Collegio Volta via A. Ferrata 17, 27100 Pavia. Tel +39 0382 548511. Web http://www.collegiovolta.org/

The Department of Molecular Medicine, in collaboration with the A. Volta and F.lli Cairoli Colleges, is pleased to invite you to the seminar of Prof. Jules Hoffmann, Nobel Prize Laureate for Medicine and Physiology in 2011, entitled: "Evolution of Innate Immunity".

The seminar will take place in Aula Ugo Foscolo (Strada nuova, n.65, Pavia) starting at 5 p.m.

For further information write to E. Gherardi <egherard@unipv.it> or A. Zatti <andrea.zatti@unipv.it>

Dr. Stephanie Strohbuecker (The Francis Crick Institute, London - UK) will give a seminar entitled "Multi-omic Data Analysis: Understanding Neural Differentiation".

Using two experimental examples, Dr. Strohbuecker will present analysis approaches for a range of sequencing modalities including single-cell RNA, ChIP- and ATAC-sequencing.

The seminar will be held on 31 March 2023 at 2 pm in the New Polo Didattico ("melanzana" building) Aula 2, Via Ferrata.

Info: virginie.sottile@unipv.it

On December 13, at the A. Volta College, Prof. Francesco Pappalardo of the University of Catania will hold a seminar entitled "Modeling cells and molecular interactions towards the immune system".

Francesco Pappalardo deals with the development of in silico biological models capable of reproducing the complexity of cellular and molecular interactions that are observed in humans in physiological and pathological conditions. He is one of the pioneers of in silico trials and coordinator of the European project "In Silico World".

For information and details, check the attached .pdf or write to E. Gherardi <egherard@unipv.it>, A. Palladini <arianna.palladini@unipv.it>

Collegio A. Volta, via A. Ferrata 17, 27100 Pavia. Tel ++39 0382 548511. Web http://collegiovolta.org/

The Department of Molecular Medicine is pleased to invite you to the seminar of Prof. Pier-Luigi Lollini (University of Bologna), entiteld:

"Vaccines for prevention and therapy of mammary carcinoma"

The seminar will be held at the "Collegio A. Volta", in via A Ferrata 17 in Pavia, on October 18th at 17:00.

(Tel 39 0382 548511, http://www.collegiovolta.org/ )

Info: egherard@unipv.it

The Department of Molecular Medicine is pleased to invite you to the seminar of Prof. R. Sugimura (Hong Kong University), entitled:

"Spatiotemporal gene expression landscape of human embryonic organoids"

The seminar will be held at the "Collegio A. Volta", in via A Ferrata 17 in Pavia, on September 26th at 17:00.

(Tel +39 0382 548511, http://www.collegiovolta.org/ )

Info: egherard@unipv.it

The preparation of the new department website officially begins.