Myeloid neoplasms - Luca Malcovati

Luca Malcovati, PI

Email: lmalcov@unipv.it

Phone: +39 0382 503062

Chiara Elena (MD)

Elisa Bono (MD)

Elisabetta Molteni (PhD)

Sara Pozzi (BSc)

Martina Sarchi (PhD Student)

Jacqueline Ferrari (MD)

Nicolas Fiorelli (MD)

Virginia Camilotto (MD)

Myeloid neoplasms include myelodysplastic syndromes, myeloproliferative neoplasms, myelodysplastic/myeloproliferative neoplasms, mastocytosis and acute myeloid leukemia.

The research activity of Luca Malcovati's group has been mainly focused on myeloid neoplasms with myelodysplasia, comprising myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, and acute myeloid leukemia.

The activity was first devoted to the identification of novel prognostic factors and models.

More recently, it has been focused to the understanding of the molecular basis of these malignancies, providing relevant contributions to the discovery of somatic mutations in splicing factors, to the unveiling of biological and clinical implications of driver mutations, and to the recognition of disease entities defined based on their genetic profile.

Research activity is currently mainly aimed at understanding clonal dynamics and mechanisms of clonal progression, elucidating the role of bone marrow microenvironment in clonal selection and expansion, developing pre-clinical disease models and novel therapeutic approaches based on cell- and antibody-mediated immunotherapy and small molecule inhibition, as well as personalized protocols for minimal residual disease.

Gallì A, Todisco G, Catamo E, Sala C, Elena C, Pozzi S, Bono E, Ferretti VV, Rizzo E, Molteni E, Zibellini S, Sarchi M, Boveri E, Ferrari J, Fiorelli N, Camaschella C, Gasparini P, Toniolo D, Cazzola M, Malcovati L. Relationship between clone metrics and clinical outcome in clonal cytopenia. Blood. 2021 Sep 16;138(11):965-976.

Malcovati L, Stevenson K, Papaemmanuil E, Neuberg D, Bejar R, Boultwood J, Bowen DT, Campbell PJ, Ebert BL, Fenaux P, Haferlach T, Heuser M, Jansen JH, Komrokji RS, Maciejewski JP, Walter MJ, Fontenay M, Garcia-Manero G, Graubert TA, Karsan A, Meggendorfer M, Pellagatti A, Sallman DA, Savona MR, Sekeres MA, Steensma DP, Tauro S, Thol F, Vyas P, Van de Loosdrecht AA, Haase D, Tüchler H, Greenberg PL, Ogawa S, Hellstrom-Lindberg E, Cazzola M. SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS. Blood. 2020 Jul 9;136(2):157-170.

Malcovati L, Gallì A, Travaglino E, Ambaglio I, Rizzo E, Molteni E, Elena C, Ferretti VV, Catricalà S, Bono E, Todisco G, Bianchessi A, Rumi E, Zibellini S, Pietra D, Boveri E, Camaschella C, Toniolo D, Papaemmanuil E, Ogawa S, Cazzola M. Clinical significance of somatic mutation in unexplained blood cytopenia. Blood. 2017 Jun 22;129(25):3371-3378.

Klampfl T, Gisslinger H, Harutyunyan AS, Nivarthi H, Rumi E, Milosevic JD, Them NC, Berg T, Gisslinger B, Pietra D, Chen D, Vladimer GI, Bagienski K, Milanesi C, Casetti IC, Sant'Antonio E, Ferretti V, Elena C, Schischlik F, Cleary C, Six M, Schalling M, Schönegger A, Bock C, Malcovati L, Pascutto C, Superti-Furga G, Cazzola M, Kralovics R. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013 Dec 19;369(25):2379-90 [IF 2020: 91.245]. Web of Science Highly Cited Paper.

Papaemmanuil E, Cazzola M, Boultwood J, Malcovati L, Vyas P, Bowen D, Pellagatti A, Wainscoat JS, Hellstrom-Lindberg E, Gambacorti-Passerini C, Godfrey AL, Rapado I, Cvejic A, Rance R, McGee C, Ellis P, Mudie LJ, Stephens PJ, McLaren S, Massie CE, Tarpey PS, Varela I, Nik-Zainal S, Davies HR, Shlien A, Jones D, Raine K, Hinton J, Butler AP, Teague JW, Baxter EJ, Score J, Galli A, Della Porta MG, Travaglino E, Groves M, Tauro S, Munshi NC, Anderson KC, El-Naggar A, Fischer A, Mustonen V, Warren AJ, Cross NC, Green AR, Futreal PA, Stratton MR, Campbell PJ; Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 2011 Oct 13;365(15):1384-95.